A study done across 561 districts (divided into intervention and control arm 1:1) to see if there’s change in notified TB cases 12, 24, 36 months post intervention with BCG vaccination.
Official Links
tb-win-lb.mohfw.gov.in: It is a digital portal created to register and record the vaccination of the identified category of people with BCG to facilitate followup as part of the Adult BCG vaccination study. (Note: This site might not open on Firefox)
The homepage (archive link) of this site has an overview of what the study is about, inclusion criteria, and workflow from mapping till AEFI reporting.
The FAQ page (archive link) has answers to questions like “Where to report AEFIs?”
ntep.in: This is a knowledge base for the National TB Elimination Program
- https://ntep.in/node/6349/orientation-adult-bcg-vaccination-protocol
- https://ntep.in/km-nodes?title=vaccination
Studies
Background:
- The potential impact of vaccination on tuberculosis burden in India: A modelling analysis https://journals.lww.com/ijmr/fulltext/2023/02000/the_potential_impact_of_vaccination_on.3.aspx
- New tuberculosis vaccines in India: modelling the potential health and economic impacts of adolescent/adult vaccination with M72/AS01E and BCG-revaccination https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-02992-7
India:
- Revisiting the Chingleput BCG vaccination trial for the impact of BCG revaccination on the incidence of tuberculosis disease https://journals.lww.com/ijmr/fulltext/2023/02000/revisiting_the_chingleput_bcg_vaccination_trial.7.aspx
South Africa:
- BCG Revaccination for the Prevention of Mycobacterium tuberculosis Infection https://pmc.ncbi.nlm.nih.gov/articles/PMC12061034/
Brazil
- Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial https://pmc.ncbi.nlm.nih.gov/articles/PMC11111441/
- Evidence of an effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: second report of the BCG-REVAC cluster-randomised trial https://pubmed.ncbi.nlm.nih.gov/21616115/
Malawi
- BCG re-vaccination in Malawi: 30-year follow-up of a large, randomised, double-blind, placebo-controlled trial https://pmc.ncbi.nlm.nih.gov/articles/PMC8459381/
Articles about the Indian study
- BCG revaccination study in high-risk adults to begin in 23 States https://www.thehindu.com/sci-tech/bcg-revaccination-study-in-high-risk-adults-to-begin-in-23-states/article67594580.ece
- Is India’s TB-WIN a game changing tool to end Tuberculosis? https://www.undp.org/india/stories/indias-tb-win-game-changing-tool-end-tuberculosis
Links about on-the-ground experience of the study
- Many adults take BCG vaccine in city not knowing they’re part of govt study https://timesofindia.indiatimes.com/city/mumbai/many-adults-take-bcg-vaccine-in-city-not-knowing-theyre-part-of-govt-study/articleshow/119724217.cms (Tweet)
- A poster from Bengal: https://www.facebook.com/photo/?fbid=1077843467719594&set=pcb.1077843534386254
- Experience from Maharashtra, Delhi, Himachal Pradesh, previous studies, on the ground, consent forms, etc shared in mfc e-group: https://groups.google.com/g/mfccircle/c/DvIStDtYDvU/m/VBClvXfVAQAJ (accessible only for members)
- Pus lesions documented in mfc thread: https://groups.google.com/g/mfccircle/c/wS3pUBheQQo/m/1H9MkJAxCQAJ (accessible only for members)
Related Links
- BCG World Atlas (http://www.bcgatlas.org/): information on current and past BCG vaccination policies and practices for over 200 countries.
- CDC guide on TB control in healthcare settings: https://www.cdc.gov/tb-healthcare-settings/hcp/infection-control/index.html
- CDC guide on BCG: https://www.cdc.gov/tb/hcp/vaccines/